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Characterization of cancer-associated IDH2 mutations that differ in tumorigenicity, chemosensitivity and 2-hydroxyglutarate production
The family of isocitrate dehydrogenase (IDH) enzymes is vital for cellular metabolism, as IDH1 and IDH2 are required for the decarboxylation of isocitrate to α-ketoglutarate. Heterozygous somatic mutations in IDH1 or IDH2 genes have been detected in many cancers. They share the neomorphic production...
Autores principales: | Kotredes, Kevin P., Razmpour, Roshanak, Lutton, Evan, Alfonso-Prieto, Mercedes, Ramirez, Servio H., Gamero, Ana M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505628/ https://www.ncbi.nlm.nih.gov/pubmed/31105869 http://dx.doi.org/10.18632/oncotarget.26848 |
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