Efficacy of simultaneous VEGF‐A/ANG‐2 neutralization in suppressing spontaneous choroidal neovascularization

This study independently confirms in vivo in the JR5558 mouse model of aberrant retinal angiogenesis, that simultaneous VEGF‐A and ANG‐2 neutralization using a bispecific anti‐VEGF‐A/ANG‐2 antibody reduces vascular leakage, immune reactivity and apoptosis more effectively than either agent alone.[Im...

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Detalles Bibliográficos
Autores principales: Foxton, Richard H, Uhles, Sabine, Grüner, Sabine, Revelant, Franco, Ullmer, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505683/
https://www.ncbi.nlm.nih.gov/pubmed/31040126
http://dx.doi.org/10.15252/emmm.201810204
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author Foxton, Richard H
Uhles, Sabine
Grüner, Sabine
Revelant, Franco
Ullmer, Christoph
author_facet Foxton, Richard H
Uhles, Sabine
Grüner, Sabine
Revelant, Franco
Ullmer, Christoph
author_sort Foxton, Richard H
collection PubMed
description This study independently confirms in vivo in the JR5558 mouse model of aberrant retinal angiogenesis, that simultaneous VEGF‐A and ANG‐2 neutralization using a bispecific anti‐VEGF‐A/ANG‐2 antibody reduces vascular leakage, immune reactivity and apoptosis more effectively than either agent alone.[Image: see text]
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spelling pubmed-65056832019-05-10 Efficacy of simultaneous VEGF‐A/ANG‐2 neutralization in suppressing spontaneous choroidal neovascularization Foxton, Richard H Uhles, Sabine Grüner, Sabine Revelant, Franco Ullmer, Christoph EMBO Mol Med Correspondence This study independently confirms in vivo in the JR5558 mouse model of aberrant retinal angiogenesis, that simultaneous VEGF‐A and ANG‐2 neutralization using a bispecific anti‐VEGF‐A/ANG‐2 antibody reduces vascular leakage, immune reactivity and apoptosis more effectively than either agent alone.[Image: see text] John Wiley and Sons Inc. 2019-04-30 2019-05 /pmc/articles/PMC6505683/ /pubmed/31040126 http://dx.doi.org/10.15252/emmm.201810204 Text en © 2019 F. Hoffmann‐La Roche AG Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Correspondence
Foxton, Richard H
Uhles, Sabine
Grüner, Sabine
Revelant, Franco
Ullmer, Christoph
Efficacy of simultaneous VEGF‐A/ANG‐2 neutralization in suppressing spontaneous choroidal neovascularization
title Efficacy of simultaneous VEGF‐A/ANG‐2 neutralization in suppressing spontaneous choroidal neovascularization
title_full Efficacy of simultaneous VEGF‐A/ANG‐2 neutralization in suppressing spontaneous choroidal neovascularization
title_fullStr Efficacy of simultaneous VEGF‐A/ANG‐2 neutralization in suppressing spontaneous choroidal neovascularization
title_full_unstemmed Efficacy of simultaneous VEGF‐A/ANG‐2 neutralization in suppressing spontaneous choroidal neovascularization
title_short Efficacy of simultaneous VEGF‐A/ANG‐2 neutralization in suppressing spontaneous choroidal neovascularization
title_sort efficacy of simultaneous vegf‐a/ang‐2 neutralization in suppressing spontaneous choroidal neovascularization
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505683/
https://www.ncbi.nlm.nih.gov/pubmed/31040126
http://dx.doi.org/10.15252/emmm.201810204
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