Cargando…

Cdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain

Neuropathic pain results from nerve injuries that cause ectopic firing and increased nociceptive signal transmission due to activation of key membrane receptors and channels. The dysregulation of trafficking of voltage-gated ion channels is an emerging mechanism in the etiology of neuropathic pain....

Descripción completa

Detalles Bibliográficos
Autores principales:	Moutal, Aubin, Luo, Shizhen, Largent-Milnes, Tally M., Vanderah, Todd W., Khanna, Rajesh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505708/ https://www.ncbi.nlm.nih.gov/pubmed/31080913 http://dx.doi.org/10.1016/j.ynpai.2018.07.003

Ejemplares similares

CRMP2 is necessary for Neurofibromatosis type 1 related pain
por: Moutal, Aubin, et al.
Publicado: (2017)

Differential expression of Cdk5-phosphorylated CRMP2 following a spared nerve injury
por: Moutal, Aubin, et al.
Publicado: (2020)

The Effects of Repeated Morphine Treatment on the Endogenous Cannabinoid System in the Ventral Tegmental Area
por: Zhang, Hong, et al.
Publicado: (2021)

Evaluation of edonerpic maleate as a CRMP2 inhibitor for pain relief
por: Moutal, Aubin, et al.
Publicado: (2019)

Use of Animal Models in Understanding Cancer-induced Bone Pain
por: Slosky, Lauren M, et al.
Publicado: (2015)

Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides
por: Moutal, Aubin, et al.
Publicado: (2015)

Activity of T-type calcium channels is independent of CRMP2 in sensory neurons
por: Cai, Song, et al.
Publicado: (2019)

Genetic and pharmacological antagonism of NK(1) receptor prevents opiate abuse potential
por: Sandweiss, Alexander J., et al.
Publicado: (2017)

PNA6, a Lactosyl Analogue of Angiotensin-(1-7), Reverses Pain Induced in Murine Models of Inflammation, Chemotherapy-Induced Peripheral Neuropathy, and Metastatic Bone Disease
por: Sulaiman, Maha I., et al.
Publicado: (2023)

Neuronal CRMP2 phosphorylation inhibition by the flavonoid, naringenin, contributes to the reversal of spinal sensitization and arthritic pain improvement
por: Jiang, Yue-Peng, et al.
Publicado: (2022)

CRMP2 and voltage-gated ion channels: potential roles in neuropathic pain
por: Chew, Lindsey A., et al.
Publicado: (2018)

The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth
por: Wilson, Sarah M., et al.
Publicado: (2014)

The endocannabinoid system and breathing
por: Wiese, Beth M., et al.
Publicado: (2023)

Non-SUMOylated CRMP2 decreases Na(V)1.7 currents via the endocytic proteins Numb, Nedd4-2 and Eps15
por: Gomez, Kimberly, et al.
Publicado: (2021)

Targeting 5-HT(2A) receptors and Kv7 channels in PFC to attenuate chronic neuropathic pain in rats using a spared nerve injury model
por: Vizcarra, Velia S., et al.
Publicado: (2022)

Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels
por: François-Moutal, Liberty, et al.
Publicado: (2018)

17-β-Estradiol induces spreading depression and pain behavior in alert female rats
por: Sandweiss, Alexander J., et al.
Publicado: (2017)

DAGLα Inhibition as a Non-invasive and Translational Model of Episodic Headache
por: Levine, Aidan, et al.
Publicado: (2021)

Differential regulation of collapsin response mediator protein 2 (CRMP2) phosphorylation by GSK3ß and CDK5 following traumatic brain injury
por: Wilson, Sarah M., et al.
Publicado: (2014)

Angiotensin-(1-7)/Mas receptor as an antinociceptive agent in cancer-induced bone pain
por: Forte, Brittany L., et al.
Publicado: (2016)

Editorial: Novel Molecular Targets for the Treatment of Pain
por: Largent-Milnes, Tally M., et al.
Publicado: (2020)

ABHD6 and MAGL control 2-AG levels in the PAG and allodynia in a CSD-induced periorbital model of headache
por: Liktor-Busa, Erika, et al.
Publicado: (2023)

Phosphorylation of CRMP2 by Cdk5 Regulates Dendritic Spine Development of Cortical Neuron in the Mouse Hippocampus
por: Jin, Xiaohua, et al.
Publicado: (2016)

1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain
por: Zhou, Yuan, et al.
Publicado: (2020)

Sex differences in the expression of the endocannabinoid system within V1M cortex and PAG of Sprague Dawley rats
por: Levine, Aidan, et al.
Publicado: (2021)

CRMP2 Is Involved in Regulation of Mitochondrial Morphology and Motility in Neurons
por: Brustovetsky, Tatiana, et al.
Publicado: (2021)

Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery
por: Cottier, Karissa E., et al.
Publicado: (2018)

Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces and prevents pain chronification in a mouse model of oxaliplatin-induced neuropathic pain
por: Braden, Kathryn, et al.
Publicado: (2021)

Involvement of CRMP2 in Regulation of Mitochondrial Morphology and Motility in Huntington’s Disease
por: Brustovetsky, Tatiana, et al.
Publicado: (2021)

CRMP2 Participates in Regulating Mitochondrial Morphology and Motility in Alzheimer’s Disease
por: Brustovetsky, Tatiana, et al.
Publicado: (2023)

Molecular mechanisms of hormones implicated in migraine and the translational implication for transgender patients
por: Martinez, Cameron I., et al.
Publicado: (2023)

Putative roles of SLC7A5 (LAT1) transporter in pain
por: Alles, Sascha R.A., et al.
Publicado: (2020)

Extracellular Alterations in pH and K+ Modify the Murine Brain Endothelial Cell Total and Phospho-Proteome
por: Wahl, Jared R., et al.
Publicado: (2022)

mTORc1 activity is necessary and sufficient for phosphorylation of eNOS(S1177)
por: Decker, Brandee, et al.
Publicado: (2018)

TNF-α mediated upregulation of Na(V)1.7 currents in rat dorsal root ganglion neurons is independent of CRMP2 SUMOylation
por: de Macedo, Flávio Henrique Pequeno, et al.
Publicado: (2019)

Functional NHE1 expression is critical to blood brain barrier integrity and sumatriptan blood to brain uptake
por: Liktor-Busa, Erika, et al.
Publicado: (2020)

Necessary or Sufficient Condition for Gastroscopy
por: Chung, Min Suk
Publicado: (2019)

Neuronal function is necessary but not sufficient for consciousness: consciousness is necessary for will
por: Nussbaum, David, et al.
Publicado: (2012)

The cystine/glutamate antiporter system x(c)(−) drives breast tumor cell glutamate release and cancer-induced bone pain
por: Slosky, Lauren M., et al.
Publicado: (2016)

Temperature Differentially Facilitates Spontaneous but Not Evoked Glutamate Release from Cranial Visceral Primary Afferents
por: Fawley, Jessica A., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_n9jcsl1hf8cgev97m7e8dcmr3t