The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity

The transient build-up of DNA supercoiling during the translocation of replication forks threatens genome stability and is controlled by DNA topoisomerases (TOPs). This crucial process has been exploited with TOP poisons for cancer chemotherapy. However, pinpointing cellular determinants of the best...

Descripción completa

Detalles Bibliográficos
Autores principales: Ahmed, Syed Moiz, Ramani, Priya Dharshana, Wong, Stephen Qi Rong, Zhao, Xiaodan, Ivanyi-Nagy, Roland, Leong, Tang Choong, Chua, Clarinda, Li, Zhizhong, Hentze, Hannes, Tan, Iain BeeHuat, Yan, Jie, DasGupta, Ramanuj, Dröge, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505889/
https://www.ncbi.nlm.nih.gov/pubmed/31067275
http://dx.doi.org/10.1371/journal.pone.0215696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505889/
https://www.ncbi.nlm.nih.gov/pubmed/31067275
http://dx.doi.org/10.1371/journal.pone.0215696

Ejemplares similares