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The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity
The transient build-up of DNA supercoiling during the translocation of replication forks threatens genome stability and is controlled by DNA topoisomerases (TOPs). This crucial process has been exploited with TOP poisons for cancer chemotherapy. However, pinpointing cellular determinants of the best...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505889/ https://www.ncbi.nlm.nih.gov/pubmed/31067275 http://dx.doi.org/10.1371/journal.pone.0215696 |