Identification of a potential allosteric site of Golgi α-mannosidase II using computer-aided drug design

Golgi α-mannosidase II (GMII) is a glycoside hydrolase playing a crucial role in the N-glycosylation pathway. In various tumour cell lines, the distribution of N-linked sugars on the cell surface is modified and correlates with the progression of tumour metastasis. GMII therefore is a possible molec...

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Detalles Bibliográficos
Autores principales: Irsheid, Lina, Wehler, Thomas, Borek, Christoph, Kiefer, Werner, Brenk, Ruth, Ortiz-Soto, Maria Elena, Seibel, Jürgen, Schirmeister, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505943/
https://www.ncbi.nlm.nih.gov/pubmed/31067280
http://dx.doi.org/10.1371/journal.pone.0216132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505943/
https://www.ncbi.nlm.nih.gov/pubmed/31067280
http://dx.doi.org/10.1371/journal.pone.0216132

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