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DNA Polymerase alpha is essential for intracellular amplification of hepatitis B virus covalently closed circular DNA
Persistent hepatitis B virus (HBV) infection relies on the establishment and maintenance of covalently closed circular (ccc) DNA, a 3.2 kb episome that serves as a viral transcription template, in the nucleus of an infected hepatocyte. Although evidence suggests that cccDNA is the repair product of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505960/ https://www.ncbi.nlm.nih.gov/pubmed/31026293 http://dx.doi.org/10.1371/journal.ppat.1007742 |