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AMPK activation regulates P-body dynamics in mouse sensory neurons in vitro and in vivo
Increased mRNA translation in sensory neurons following peripheral nerve injury contributes to the induction and maintenance of chronic neuropathic pain. Metformin, a common anti-diabetic drug and an activator of AMP-activated protein kinase (AMPK), inhibits cap-dependent mRNA translation and revers...
Autores principales: | Paige, Candler, Mejia, Galo, Dussor, Gregory, Price, Theodore |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506165/ https://www.ncbi.nlm.nih.gov/pubmed/31080914 http://dx.doi.org/10.1016/j.ynpai.2018.100026 |
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