Production of CRISPR/Cas9-Mediated Self-Cleaving Helper-Dependent Adenoviruses

Prolonged expression of CRISPR/Cas9 raises concerns about off-target cleavage, cytotoxicity, and immune responses. To address these issues, we have developed a system to produce helper-dependent adenoviruses that express CRISPR/Cas9 to direct cleavage of the vectors’ own genome after transduction of...

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Detalles Bibliográficos
Autores principales: Palmer, Donna J., Turner, Dustin L., Ng, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506437/
https://www.ncbi.nlm.nih.gov/pubmed/31080846
http://dx.doi.org/10.1016/j.omtm.2019.04.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506437/
https://www.ncbi.nlm.nih.gov/pubmed/31080846
http://dx.doi.org/10.1016/j.omtm.2019.04.003

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