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Soluble expression of proteins correlates with a lack of positively-charged surface

Prediction of protein solubility is gaining importance with the growing use of protein molecules as therapeutics, and ongoing requirements for high level expression. We have investigated protein surface features that correlate with insolubility. Non-polar surface patches associate to some degree wit...

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Detalles Bibliográficos
Autores principales: Chan, Pedro, Curtis, Robin A., Warwicker, Jim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506438/
https://www.ncbi.nlm.nih.gov/pubmed/24276756
http://dx.doi.org/10.1038/srep03333