Neuralized family member NEURL1 is a ubiquitin ligase for the cGMP-specific phosphodiesterase 9A

Neuralized functions as a positive regulator of the Notch pathway by promoting ubiquitination of Notch ligands via its E3 ligase activity, resulting in their efficient endocytosis and signaling. Using a yeast two-hybrid screen, we have identified a cGMP-hydrolysing phosphodiesterase, PDE9A, as a nov...

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Detalles Bibliográficos
Autores principales: Taal, Kati, Tuvikene, Jürgen, Rullinkov, Grete, Piirsoo, Marko, Sepp, Mari, Neuman, Toomas, Tamme, Richard, Timmusk, Tõnis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506465/
https://www.ncbi.nlm.nih.gov/pubmed/31068605
http://dx.doi.org/10.1038/s41598-019-43069-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506465/
https://www.ncbi.nlm.nih.gov/pubmed/31068605
http://dx.doi.org/10.1038/s41598-019-43069-x

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