Structure of Mycobacterium tuberculosis phosphatidylinositol phosphate synthase reveals mechanism of substrate binding and metal catalysis

Tuberculosis causes over one million yearly deaths, and drug resistance is rapidly developing. Mycobacterium tuberculosis phosphatidylinositol phosphate synthase (PgsA1) is an integral membrane enzyme involved in biosynthesis of inositol-derived phospholipids required for formation of the mycobacter...

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Detalles Bibliográficos
Autores principales: Grāve, Kristīne, Bennett, Matthew D., Högbom, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506517/
https://www.ncbi.nlm.nih.gov/pubmed/31098408
http://dx.doi.org/10.1038/s42003-019-0427-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506517/
https://www.ncbi.nlm.nih.gov/pubmed/31098408
http://dx.doi.org/10.1038/s42003-019-0427-1

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