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Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease
Ribosome biogenesis is a canonical hallmark of cell growth and proliferation. Here we show that execution of Epithelial-to-Mesenchymal Transition (EMT), a migratory cellular program associated with development and tumor metastasis, is fueled by upregulation of ribosome biogenesis during G1/S arrest....
Autores principales: | Prakash, Varsha, Carson, Brittany B., Feenstra, Jennifer M., Dass, Randall A., Sekyrova, Petra, Hoshino, Ayuko, Petersen, Julian, Guo, Yuan, Parks, Matthew M., Kurylo, Chad M., Batchelder, Jake E., Haller, Kristian, Hashimoto, Ayako, Rundqivst, Helene, Condeelis, John S., Allis, C. David, Drygin, Denis, Nieto, M. Angela, Andäng, Michael, Percipalle, Piergiorgio, Bergh, Jonas, Adameyko, Igor, Farrants, Ann-Kristin Östlund, Hartman, Johan, Lyden, David, Pietras, Kristian, Blanchard, Scott C., Vincent, C. Theresa |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506521/ https://www.ncbi.nlm.nih.gov/pubmed/31068593 http://dx.doi.org/10.1038/s41467-019-10100-8 |
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