Alternative cleavage and polyadenylation of genes associated with protein turnover and mitochondrial function are deregulated in Parkinson’s, Alzheimer’s and ALS disease

BACKGROUND: Transcriptome wide changes have been assessed extensively during the progression of neurodegenerative diseases. Alternative polyadenylation (APA) occurs in over 70% of human protein coding genes and it has recently been recognised as a critical regulator of gene expression during disease...

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Detalles Bibliográficos
Autores principales: Patel, Radhika, Brophy, Cillian, Hickling, Mark, Neve, Jonathan, Furger, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507032/
https://www.ncbi.nlm.nih.gov/pubmed/31072331
http://dx.doi.org/10.1186/s12920-019-0509-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507032/
https://www.ncbi.nlm.nih.gov/pubmed/31072331
http://dx.doi.org/10.1186/s12920-019-0509-4

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