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Preclinical characterization of AMPA receptor potentiator TAK‐137 as a therapeutic drug for schizophrenia

The downregulation of the glutamate system may be involved in positive, negative, and cognitive symptoms of schizophrenia. Through enhanced glutamate signaling, the activation of the α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole‐propionic acid (AMPA) receptor, an ionotropic glutamate receptor, could be a n...

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Detalles Bibliográficos
Autores principales: Tanaka, Maiko, Kunugi, Akiyoshi, Suzuki, Atsushi, Suzuki, Noriko, Suzuki, Motohisa, Kimura, Haruhide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507438/
https://www.ncbi.nlm.nih.gov/pubmed/31086673
http://dx.doi.org/10.1002/prp2.479