Sirtuin 1 knockdown inhibits glioma cell proliferation and potentiates temozolomide toxicity via facilitation of reactive oxygen species generation

Malignant glioma is one of the most common types of primary malignancies in the human central nervous system. Temozolomide (TMZ) is the most commonly used drug in clinical therapy of glioma; however, chemoresistance makes glioma difficult to cure and relapse likely. Sirtuin 1 (SIRT1) serves importan...

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Detalles Bibliográficos
Autores principales: Chen, Hongwu, Lin, Rui, Zhang, Ziheng, Wei, Quantang, Zhong, Zhiwei, Huang, Jiehao, Xu, Yimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507466/
https://www.ncbi.nlm.nih.gov/pubmed/31186751
http://dx.doi.org/10.3892/ol.2019.10235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507466/
https://www.ncbi.nlm.nih.gov/pubmed/31186751
http://dx.doi.org/10.3892/ol.2019.10235

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