A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle

Dengue virus (DENV) has emerged as major human pathogen. Despite the serious socio-economic impact of DENV-associated diseases, antiviral therapy is missing. DENV replicates in the cytoplasm of infected cells and induces a membranous replication organelle, formed by invaginations of the endoplasmic...

Descripción completa

Detalles Bibliográficos
Autores principales: Płaszczyca, Anna, Scaturro, Pietro, Neufeldt, Christopher John, Cortese, Mirko, Cerikan, Berati, Ferla, Salvatore, Brancale, Andrea, Pichlmair, Andreas, Bartenschlager, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508626/
https://www.ncbi.nlm.nih.gov/pubmed/31071189
http://dx.doi.org/10.1371/journal.ppat.1007736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508626/
https://www.ncbi.nlm.nih.gov/pubmed/31071189
http://dx.doi.org/10.1371/journal.ppat.1007736

Ejemplares similares