Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons

Loss of the nuclear RNA binding protein TAR DNA binding protein-43 (TDP-43) into cytoplasmic aggregates is the strongest correlate to neurodegeneration in amyotrophic lateral sclerosis and frontotemporal degeneration. The molecular changes associated with the loss of nuclear TDP-43 in human tissues...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Elaine Y., Russ, Jenny, Cali, Christopher P., Phan, Jessica M., Amlie-Wolf, Alexandre, Lee, Edward B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508629/
https://www.ncbi.nlm.nih.gov/pubmed/31042469
http://dx.doi.org/10.1016/j.celrep.2019.04.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508629/
https://www.ncbi.nlm.nih.gov/pubmed/31042469
http://dx.doi.org/10.1016/j.celrep.2019.04.003

Ejemplares similares