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Host metabolites stimulate the bacterial proton motive force to enhance the activity of aminoglycoside antibiotics
Antibiotic susceptibility of bacterial pathogens is typically evaluated using in vitro assays that do not consider the complex host microenvironment. This may help explaining a significant discrepancy between antibiotic efficacy in vitro and in vivo, with some antibiotics being effective in vitro bu...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508747/ https://www.ncbi.nlm.nih.gov/pubmed/31034512 http://dx.doi.org/10.1371/journal.ppat.1007697 |