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Host metabolites stimulate the bacterial proton motive force to enhance the activity of aminoglycoside antibiotics

Antibiotic susceptibility of bacterial pathogens is typically evaluated using in vitro assays that do not consider the complex host microenvironment. This may help explaining a significant discrepancy between antibiotic efficacy in vitro and in vivo, with some antibiotics being effective in vitro bu...

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Detalles Bibliográficos
Autores principales:	Crabbé, Aurélie, Ostyn, Lisa, Staelens, Sorien, Rigauts, Charlotte, Risseeuw, Martijn, Dhaenens, Maarten, Daled, Simon, Van Acker, Heleen, Deforce, Dieter, Van Calenbergh, Serge, Coenye, Tom
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508747/ https://www.ncbi.nlm.nih.gov/pubmed/31034512 http://dx.doi.org/10.1371/journal.ppat.1007697

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