Circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system

Oligodendrocyte maturation is necessary for functional regeneration in the CNS; however, the mechanisms by which the systemic environment regulates oligodendrocyte maturation is unclear. We found that Transforming growth factor (TGF)-β1, which is present in higher levels in the systemic environment,...

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Autores principales: Hamaguchi, Machika, Muramatsu, Rieko, Fujimura, Harutoshi, Mochizuki, Hideki, Kataoka, Hirotoshi, Yamashita, Toshihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508935/
https://www.ncbi.nlm.nih.gov/pubmed/31071011
http://dx.doi.org/10.7554/eLife.41869
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author Hamaguchi, Machika
Muramatsu, Rieko
Fujimura, Harutoshi
Mochizuki, Hideki
Kataoka, Hirotoshi
Yamashita, Toshihide
author_facet Hamaguchi, Machika
Muramatsu, Rieko
Fujimura, Harutoshi
Mochizuki, Hideki
Kataoka, Hirotoshi
Yamashita, Toshihide
author_sort Hamaguchi, Machika
collection PubMed
description Oligodendrocyte maturation is necessary for functional regeneration in the CNS; however, the mechanisms by which the systemic environment regulates oligodendrocyte maturation is unclear. We found that Transforming growth factor (TGF)-β1, which is present in higher levels in the systemic environment, promotes oligodendrocyte maturation. Oligodendrocyte maturation was enhanced by adult mouse serum treatment via TGF-β type I receptor. Decrease in circulating TGF-β1 level prevented remyelination in the spinal cord after toxin-induced demyelination. TGF-β1 administration promoted remyelination and restored neurological function in a multiple sclerosis animal model. Furthermore, TGF-β1 treatment stimulated human oligodendrocyte maturation. These data provide the therapeutic possibility of TGF-β for demyelinating diseases.
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spelling pubmed-65089352019-05-10 Circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system Hamaguchi, Machika Muramatsu, Rieko Fujimura, Harutoshi Mochizuki, Hideki Kataoka, Hirotoshi Yamashita, Toshihide eLife Neuroscience Oligodendrocyte maturation is necessary for functional regeneration in the CNS; however, the mechanisms by which the systemic environment regulates oligodendrocyte maturation is unclear. We found that Transforming growth factor (TGF)-β1, which is present in higher levels in the systemic environment, promotes oligodendrocyte maturation. Oligodendrocyte maturation was enhanced by adult mouse serum treatment via TGF-β type I receptor. Decrease in circulating TGF-β1 level prevented remyelination in the spinal cord after toxin-induced demyelination. TGF-β1 administration promoted remyelination and restored neurological function in a multiple sclerosis animal model. Furthermore, TGF-β1 treatment stimulated human oligodendrocyte maturation. These data provide the therapeutic possibility of TGF-β for demyelinating diseases. eLife Sciences Publications, Ltd 2019-05-09 /pmc/articles/PMC6508935/ /pubmed/31071011 http://dx.doi.org/10.7554/eLife.41869 Text en © 2019, Hamaguchi et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Hamaguchi, Machika
Muramatsu, Rieko
Fujimura, Harutoshi
Mochizuki, Hideki
Kataoka, Hirotoshi
Yamashita, Toshihide
Circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system
title Circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system
title_full Circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system
title_fullStr Circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system
title_full_unstemmed Circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system
title_short Circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system
title_sort circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508935/
https://www.ncbi.nlm.nih.gov/pubmed/31071011
http://dx.doi.org/10.7554/eLife.41869
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