The selective disruption of presynaptic JNK2/STX1a interaction reduces NMDA receptor-dependent glutamate release

The neuronal loss caused by excessive glutamate release, or ‘excitotoxicity’, leads to several pathological conditions, including cerebral ischemia, epilepsy, and neurodegenerative diseases. Over-stimulation of presynaptic N-methyl-D-aspartate (NMDA) receptors is known to trigger and support glutama...

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Detalles Bibliográficos
Autores principales: Marcelli, Serena, Iannuzzi, Filomena, Ficulle, Elena, Mango, Dalila, Pieraccini, Stefano, Pellegrino, Sara, Corbo, Massimo, Sironi, Maurizio, Pittaluga, Anna, Nisticò, Robert, Feligioni, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509125/
https://www.ncbi.nlm.nih.gov/pubmed/31073146
http://dx.doi.org/10.1038/s41598-019-43709-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509125/
https://www.ncbi.nlm.nih.gov/pubmed/31073146
http://dx.doi.org/10.1038/s41598-019-43709-2

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