Cargando…

The selective disruption of presynaptic JNK2/STX1a interaction reduces NMDA receptor-dependent glutamate release

The neuronal loss caused by excessive glutamate release, or ‘excitotoxicity’, leads to several pathological conditions, including cerebral ischemia, epilepsy, and neurodegenerative diseases. Over-stimulation of presynaptic N-methyl-D-aspartate (NMDA) receptors is known to trigger and support glutama...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marcelli, Serena, Iannuzzi, Filomena, Ficulle, Elena, Mango, Dalila, Pieraccini, Stefano, Pellegrino, Sara, Corbo, Massimo, Sironi, Maurizio, Pittaluga, Anna, Nisticò, Robert, Feligioni, Marco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509125/ https://www.ncbi.nlm.nih.gov/pubmed/31073146 http://dx.doi.org/10.1038/s41598-019-43709-2

Ejemplares similares

Presynaptic c-Jun N-terminal Kinase 2 regulates NMDA receptor-dependent glutamate release
por: Nisticò, Robert, et al.
Publicado: (2015)

On the Role of Glutamate in Presynaptic Development: Possible Contributions of Presynaptic NMDA Receptors
por: Fedder, Karlie N., et al.
Publicado: (2015)

Presynaptic release‐regulating NMDA receptors in isolated nerve terminals: A narrative review
por: Pittaluga, Anna
Publicado: (2021)

Presynaptic Release-regulating Metabotropic Glutamate Receptors: An Update
por: Olivero, Guendalina, et al.
Publicado: (2020)

Targeting Synaptic Plasticity in Experimental Models of Alzheimer’s Disease
por: Mango, Dalila, et al.
Publicado: (2019)

Hyperhomocysteinemia as a Risk Factor and Potential Nutraceutical Target for Certain Pathologies
por: Tinelli, Caterina, et al.
Publicado: (2019)

Felbamate but not phenytoin or gabapentin reduces glutamate release by blocking presynaptic NMDA receptors in the entorhinal cortex
por: Yang, Jian, et al.
Publicado: (2007)

Targeting Microglia-Synapse Interactions in Alzheimer’s Disease
por: Piccioni, Gaia, et al.
Publicado: (2021)

Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels?
por: Mango, Dalila, et al.
Publicado: (2021)

Acid-sensing ion channel 1a: a novel target in Alzheimer’s disease?
por: Mango, Dalila, et al.
Publicado: (2022)

Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer’s disease and other tauopathies
por: Florenzano, Fulvio, et al.
Publicado: (2017)

Facilitation of neocortical presynaptic terminal development by NMDA receptor activation
por: Sceniak, Michael P, et al.
Publicado: (2012)

Target-Specific Expression of Presynaptic NMDA Receptors in Neocortical Microcircuits
por: Buchanan, Katherine A., et al.
Publicado: (2012)

Intelligence in Williams Syndrome Is Related to STX1A, Which Encodes a Component of the Presynaptic SNARE Complex
por: Gao, Michael C., et al.
Publicado: (2010)

Ginkgolic Acid Protects against Aβ-Induced Synaptic Dysfunction in the Hippocampus
por: Mango, Dalila, et al.
Publicado: (2016)

Updates on the Physiopathology of Group I Metabotropic Glutamate Receptors (mGluRI)-Dependent Long-Term Depression
por: Mango, Dalila, et al.
Publicado: (2023)

Mechanisms that Determine the Differential Stability of Stx(+) and Stx(−) Lysogens
por: Colon, Michael P., et al.
Publicado: (2016)

Presynaptic NMDA Receptors and Spike Timing-Dependent Depression at Cortical Synapses
por: Rodríguez-Moreno, Antonio, et al.
Publicado: (2010)

Presynaptic Release-Regulating mGlu1 Receptors in Central Nervous System
por: Pittaluga, Anna
Publicado: (2016)

Acute Functional Adaptations in Isolated Presynaptic Terminals Unveil Synaptosomal Learning and Memory
por: Pittaluga, Anna
Publicado: (2019)

Presynaptic 5-HT(2A)-mGlu2/3 Receptor–Receptor Crosstalk in the Prefrontal Cortex: Metamodulation of Glutamate Exocytosis
por: Taddeucci, Alice, et al.
Publicado: (2022)

Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors
por: Zhang, Rong-wei, et al.
Publicado: (2016)

Postsynaptic, not presynaptic NMDA receptors are required for spike timing dependent LTD induction
por: Carter, Brett C., et al.
Publicado: (2016)

NMDA receptor-dependent presynaptic inhibition at the calyx of Held synapse of rat pups
por: Oshima-Takago, Tomoko, et al.
Publicado: (2017)

Glutamate is required for depression but not potentiation of long-term presynaptic function
por: Padamsey, Zahid, et al.
Publicado: (2017)

A Glutamate Homeostat Controls the Presynaptic Inhibition of Neurotransmitter Release
por: Li, Xiling, et al.
Publicado: (2018)

Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release
por: Sigler, Albrecht, et al.
Publicado: (2017)

Presynaptic NMDA Receptors Mediate IPSC Potentiation at GABAergic Synapses in Developing Rat Neocortex
por: Mathew, Seena S., et al.
Publicado: (2011)

Detection of stx(1) and stx(2) Genes in Pennsylvanian White-Tailed Deer
por: Kistler, Whitney M., et al.
Publicado: (2011)

Somatostatin, a Presynaptic Modulator of Glutamatergic Signal in the Central Nervous System
por: Pittaluga, Anna, et al.
Publicado: (2021)

Switching Shiga Toxin (Stx) Type from Stx2d to Stx2a but Not Stx2c Alters Virulence of Stx-Producing Escherichia coli (STEC) Strain B2F1 in Streptomycin (Str)-Treated Mice
por: McNichol, Beth A., et al.
Publicado: (2021)

Role of Presynaptic Glutamate Receptors in Pain Transmission at the Spinal Cord Level
por: Bardoni, Rita
Publicado: (2013)

Non-canonical Mechanisms of Presynaptic Kainate Receptors Controlling Glutamate Release
por: Negrete-Díaz, José V., et al.
Publicado: (2018)

Biodistribution and elimination kinetics of systemic Stx2 by the Stx2A and Stx2B subunit-specific human monoclonal antibodies in mice
por: Sheoran, Abhineet, et al.
Publicado: (2012)

Expression and roles of glutamate (NMDA) receptors on T cell subsets
por: Orihara, Kanami, et al.
Publicado: (2010)

NMDA receptor modulation of glutamate release in activated neutrophils
por: del Arroyo, Ana Gutierrez, et al.
Publicado: (2019)

Reduced Toxicity of Shiga Toxin (Stx) Type 2c in Mice Compared to Stx2d Is Associated with Instability of Stx2c Holotoxin
por: Bunger, Joshua C., et al.
Publicado: (2015)

Identification and Characterization of ten Escherichia coli Strains Encoding Novel Shiga Toxin 2 Subtypes, Stx2n as Well as Stx2j, Stx2m, and Stx2o, in the United States
por: Lindsey, Rebecca L., et al.
Publicado: (2023)

New Stx2e Monoclonal Antibodies for Immunological Detection and Distinction of Stx2 Subtypes
por: Skinner, Craig, et al.
Publicado: (2015)

Differences in the Shiga Toxin (Stx) 2a Phage Regulatory Switch Region Influence Stx2 Localization and Virulence of Stx-Producing Escherichia coli in Mice
por: Atitkar, Rama R., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ld6ape4smi7im8u7bbncl5t66v