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MICU1 and MICU2 Play an Essential Role in Mitochondrial Ca(2+) Uptake, Growth, and Infectivity of the Human Pathogen Trypanosoma cruzi

The mitochondrial Ca(2+) uptake in trypanosomatids, which belong to the eukaryotic supergroup Excavata, shares biochemical characteristics with that of animals, which, together with fungi, belong to the supergroup Opisthokonta. However, the composition of the mitochondrial calcium uniporter (MCU) co...

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Detalles Bibliográficos
Autores principales: Bertolini, Mayara S., Chiurillo, Miguel A., Lander, Noelia, Vercesi, Anibal E., Docampo, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509184/
https://www.ncbi.nlm.nih.gov/pubmed/31064825
http://dx.doi.org/10.1128/mBio.00348-19