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Influenza “Trains” the Host for Enhanced Susceptibility to Secondary Bacterial Infection

We previously reported that the Toll-like receptor 4 (TLR4) antagonist Eritoran blocks acute lung injury (ALI) therapeutically in mouse and cotton rat models of influenza. However, secondary (2°) bacterial infection following influenza virus infection is associated with excess morbidity and mortalit...

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Detalles Bibliográficos
Autores principales: Shirey, Kari Ann, Perkins, Darren J., Lai, Wendy, Zhang, Wei, Fernando, Lurds R., Gusovsky, Fabian, Blanco, Jorge C. G., Vogel, Stefanie N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509193/
https://www.ncbi.nlm.nih.gov/pubmed/31064834
http://dx.doi.org/10.1128/mBio.00810-19