Phagocytosis of Apoptotic Cells Is Specifically Upregulated in ApoE4 Expressing Microglia in vitro

Alzheimer’s disease (AD) is characterized by intracellular tau aggregates and extracellular deposition of amyloid-β (Aβ). The major genetic risk factor to develop AD is the Apolipoprotein E isoform 4 (ApoE4). ApoE4 may directly affect Aβ pathology, yet the exact role of ApoE4 in the progression of A...

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Detalles Bibliográficos
Autores principales: Muth, Christiane, Hartmann, Alexander, Sepulveda-Falla, Diego, Glatzel, Markus, Krasemann, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509203/
https://www.ncbi.nlm.nih.gov/pubmed/31130847
http://dx.doi.org/10.3389/fncel.2019.00181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509203/
https://www.ncbi.nlm.nih.gov/pubmed/31130847
http://dx.doi.org/10.3389/fncel.2019.00181

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