Endogenous APOBEC3B Overexpression Constitutively Generates DNA Substitutions and Deletions in Myeloma Cells

Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) DNA cytosine deaminases have emerged as potential genomic mutators in various cancers. Multiple myeloma accumulates APOBEC signature mutations as it progresses; however, the mechanisms underlying APOBEC signature acquisition an...

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Detalles Bibliográficos
Autores principales: Yamazaki, Hiroyuki, Shirakawa, Kotaro, Matsumoto, Tadahiko, Hirabayashi, Shigeki, Murakawa, Yasuhiro, Kobayashi, Masayuki, Sarca, Anamaria Daniela, Kazuma, Yasuhiro, Matsui, Hiroyuki, Maruyama, Wataru, Fukuda, Hirofumi, Shirakawa, Ryutaro, Shindo, Keisuke, Ri, Masaki, Iida, Shinsuke, Takaori-Kondo, Akifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509214/
https://www.ncbi.nlm.nih.gov/pubmed/31073151
http://dx.doi.org/10.1038/s41598-019-43575-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509214/
https://www.ncbi.nlm.nih.gov/pubmed/31073151
http://dx.doi.org/10.1038/s41598-019-43575-y

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