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Inheritance of a Phenotypically Neutral Epimutation Evokes Gene Silencing in Later Generations
Small RNAs trigger the formation of epialleles that are silenced across generations. Consequently, RNA-directed epimutagenesis is associated with persistent gene repression. Here, we demonstrate that small interfering RNA-induced epimutations in fission yeast are still inherited even when the silenc...
Autores principales: | Duempelmann, Lea, Mohn, Fabio, Shimada, Yukiko, Oberti, Daniele, Andriollo, Aude, Lochs, Silke, Bühler, Marc |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509282/ https://www.ncbi.nlm.nih.gov/pubmed/30898439 http://dx.doi.org/10.1016/j.molcel.2019.02.009 |
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