MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis

In mitosis, cells inactivate DNA double-strand break (DSB) repair pathways to preserve genome stability. However, some early signaling events still occur, such as recruitment of the scaffold protein MDC1 to phosphorylated histone H2AX at DSBs. Yet, it remains unclear whether these events are importa...

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Detalles Bibliográficos
Autores principales: Leimbacher, Pia-Amata, Jones, Samuel E., Shorrocks, Ann-Marie K., de Marco Zompit, Mara, Day, Matthew, Blaauwendraad, Jordy, Bundschuh, Diana, Bonham, Sarah, Fischer, Roman, Fink, Daniel, Kessler, Benedikt M., Oliver, Antony W., Pearl, Laurence H., Blackford, Andrew N., Stucki, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509287/
https://www.ncbi.nlm.nih.gov/pubmed/30898438
http://dx.doi.org/10.1016/j.molcel.2019.02.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509287/
https://www.ncbi.nlm.nih.gov/pubmed/30898438
http://dx.doi.org/10.1016/j.molcel.2019.02.014

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