Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

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Cellular senescence entails a stable cell-cycle arrest and a pro-inflammatory secretory phenotype, which contributes to aging and age-related diseases. Obesity is associated with increased senescent cell burden and neuropsychiatric disorders, including anxiety and depression. To investigate the role...

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Detalles Bibliográficos
Autores principales: Ogrodnik, Mikolaj, Zhu, Yi, Langhi, Larissa G.P., Tchkonia, Tamar, Krüger, Patrick, Fielder, Edward, Victorelli, Stella, Ruswhandi, Rifqha A., Giorgadze, Nino, Pirtskhalava, Tamar, Podgorni, Oleg, Enikolopov, Grigori, Johnson, Kurt O., Xu, Ming, Inman, Christine, Palmer, Allyson K., Schafer, Marissa, Weigl, Moritz, Ikeno, Yuji, Burns, Terry C., Passos, João F., von Zglinicki, Thomas, Kirkland, James L., Jurk, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509403/
https://www.ncbi.nlm.nih.gov/pubmed/30612898
http://dx.doi.org/10.1016/j.cmet.2018.12.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509403/
https://www.ncbi.nlm.nih.gov/pubmed/30612898
http://dx.doi.org/10.1016/j.cmet.2018.12.008

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