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Absence of BBSome function leads to astrocyte reactivity in the brain

In humans, dysfunctional primary cilia result in Bardet-Biedl syndrome (BBS), which presents with clinical features including intellectual disabilities, obesity, and retinal degeneration, and, in mouse models, the added feature of hydrocephalus. We observed increased Glial Fibrillary Acidic Protein...

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Detalles Bibliográficos
Autores principales: Singh, Minati, Garrison, Janelle E., Wang, Kai, Sheffield, Val C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509862/
https://www.ncbi.nlm.nih.gov/pubmed/31072410
http://dx.doi.org/10.1186/s13041-019-0466-z