Interaction Mechanisms Between the NOX4/ROS and RhoA/ROCK1 Signaling Pathways as New Anti- fibrosis Targets of Ursolic Acid in Hepatic Stellate Cells

BACKGROUND: Studies have shown that both NOX4 and RhoA play essential roles in fibrosis and that they regulate each other. In lung fibrosis, NOX4/ROS is located upstream of the RhoA/ROCK1 signaling pathway, and the two molecules are oppositely located in renal fibrosis. Currently, no reports have in...

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Detalles Bibliográficos
Autores principales: Huang, Chenkai, Gan, Dakai, Luo, Fangyun, Wan, Sizhe, Chen, Jiang, Wang, Anjiang, Li, Bimin, Zhu, Xuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510285/
https://www.ncbi.nlm.nih.gov/pubmed/31130857
http://dx.doi.org/10.3389/fphar.2019.00431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510285/
https://www.ncbi.nlm.nih.gov/pubmed/31130857
http://dx.doi.org/10.3389/fphar.2019.00431

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