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EZH2 Regulates Protein Stability via Recruiting USP7 to Mediate Neuronal Gene Expression in Cancer Cells

Misexpression of chromatin modification factors and changed epigenetic modifications play crucial roles for tumorigenesis. Our previous studies demonstrated that inhibition of epigenetic modification enzymes EZH2, LSD1, DNMTs, and HDACs caused post-mitotic neuron-like differentiation in different ca...

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Detalles Bibliográficos
Autores principales: Lei, Anhua, Chen, Lu, Zhang, Min, Yang, Xiaoli, Xu, Liyang, Cao, Ning, Zhang, Zan, Cao, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510286/
https://www.ncbi.nlm.nih.gov/pubmed/31130994
http://dx.doi.org/10.3389/fgene.2019.00422