Evaluation of the Ability of Immune Humanized Mice to Demonstrate CD20‐Specific Cytotoxicity Induced by Ofatumumab

CD20 monoclonal antibodies are well‐established therapeutics for the treatment of B‐cell malignancies. Several mechanisms of target cell killing occur from anti‐CD20 therapy, including complement‐dependent cytotoxicity (CDC) cell lysis and antibody‐dependent cell‐mediated cytotoxicity. Human Fc rece...

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Detalles Bibliográficos
Autores principales: Semple, Kenrick M., Gonzaléz, Carlos M., Zarr, Melissa, Austin, José R., Patel, Vikram, Howard, Kristina E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510375/
https://www.ncbi.nlm.nih.gov/pubmed/30737892
http://dx.doi.org/10.1111/cts.12613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510375/
https://www.ncbi.nlm.nih.gov/pubmed/30737892
http://dx.doi.org/10.1111/cts.12613

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