Impact of Insulin Tregopil and Its Permeation Enhancer on Pharmacokinetics of Metformin in Healthy Volunteers: Randomized, Open‐Label, Placebo‐Controlled, Crossover Study

Oral insulin tregopil (IN‐105; a new drug under development) may be coadministered with oral antidiabetic drugs, such as metformin in patients with type 2 diabetes mellitus for optimal glycemic control. IN‐105 has sodium caprate excipient, a permeation enhancer, for enhancing absorption in the stoma...

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Detalles Bibliográficos
Autores principales: Khedkar, Anand, Lebovitz, Harold, Fleming, Alexander, Cherrington, Alan, Jose, Vinu, Athalye, Sandeep N., Vishweswaramurthy, Ashwini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510383/
https://www.ncbi.nlm.nih.gov/pubmed/30592549
http://dx.doi.org/10.1111/cts.12609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510383/
https://www.ncbi.nlm.nih.gov/pubmed/30592549
http://dx.doi.org/10.1111/cts.12609

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