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A multiscale model of epigenetic heterogeneity-driven cell fate decision-making
The inherent capacity of somatic cells to switch their phenotypic status in response to damage stimuli in vivo might have a pivotal role in ageing and cancer. However, how the entry-exit mechanisms of phenotype reprogramming are established remains poorly understood. In an attempt to elucidate such...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510448/ https://www.ncbi.nlm.nih.gov/pubmed/31039148 http://dx.doi.org/10.1371/journal.pcbi.1006592 |