Cargando…
A multiscale model of epigenetic heterogeneity-driven cell fate decision-making
The inherent capacity of somatic cells to switch their phenotypic status in response to damage stimuli in vivo might have a pivotal role in ageing and cancer. However, how the entry-exit mechanisms of phenotype reprogramming are established remains poorly understood. In an attempt to elucidate such...
Autores principales: | Folguera-Blasco, Núria, Pérez-Carrasco, Rubén, Cuyàs, Elisabet, Menendez, Javier A., Alarcón, Tomás |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510448/ https://www.ncbi.nlm.nih.gov/pubmed/31039148 http://dx.doi.org/10.1371/journal.pcbi.1006592 |
Ejemplares similares
-
Epigenetic regulation of cell fate reprogramming in aging and disease: A predictive computational model
por: Folguera-Blasco, Núria, et al.
Publicado: (2018) -
Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome
por: Menendez, Javier A., et al.
Publicado: (2016) -
In silico clinical trials for anti-aging therapies
por: Menendez, Javier A., et al.
Publicado: (2019) -
Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate
por: Vazquez-Martin, Alejandro, et al.
Publicado: (2016) -
Metabostemness: Metaboloepigenetic reprogramming of cancer stem-cell functions
por: Menendez, Javier A., et al.
Publicado: (2014)