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Sensory perception drives food avoidance through excitatory basal forebrain circuits
Appetite is driven by nutritional state, environmental cues, mood, and reward pathways. Environmental cues strongly influence feeding behavior, as they can dramatically induce or diminish the drive to consume food despite homeostatic state. Here, we have uncovered an excitatory neuronal population i...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510534/ https://www.ncbi.nlm.nih.gov/pubmed/31074744 http://dx.doi.org/10.7554/eLife.44548 |
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author | Patel, Jay M Swanson, Jessica Ung, Kevin Herman, Alexander Hanson, Elizabeth Ortiz-Guzman, Joshua Selever, Jennifer Tong, Qingchun Arenkiel, Benjamin R |
author_facet | Patel, Jay M Swanson, Jessica Ung, Kevin Herman, Alexander Hanson, Elizabeth Ortiz-Guzman, Joshua Selever, Jennifer Tong, Qingchun Arenkiel, Benjamin R |
author_sort | Patel, Jay M |
collection | PubMed |
description | Appetite is driven by nutritional state, environmental cues, mood, and reward pathways. Environmental cues strongly influence feeding behavior, as they can dramatically induce or diminish the drive to consume food despite homeostatic state. Here, we have uncovered an excitatory neuronal population in the basal forebrain that is activated by food-odor related stimuli, and potently drives hypophagia. Notably, we found that the basal forebrain directly integrates environmental sensory cues to govern feeding behavior, and that basal forebrain signaling, mediated through projections to the lateral hypothalamus, promotes selective avoidance of food and food-related stimuli. Together, these findings reveal a novel role for the excitatory basal forebrain in regulating appetite suppression through food avoidance mechanisms, highlighting a key function for this structure as a potent integrator of sensory information towards governing consummatory behaviors. |
format | Online Article Text |
id | pubmed-6510534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-65105342019-05-13 Sensory perception drives food avoidance through excitatory basal forebrain circuits Patel, Jay M Swanson, Jessica Ung, Kevin Herman, Alexander Hanson, Elizabeth Ortiz-Guzman, Joshua Selever, Jennifer Tong, Qingchun Arenkiel, Benjamin R eLife Neuroscience Appetite is driven by nutritional state, environmental cues, mood, and reward pathways. Environmental cues strongly influence feeding behavior, as they can dramatically induce or diminish the drive to consume food despite homeostatic state. Here, we have uncovered an excitatory neuronal population in the basal forebrain that is activated by food-odor related stimuli, and potently drives hypophagia. Notably, we found that the basal forebrain directly integrates environmental sensory cues to govern feeding behavior, and that basal forebrain signaling, mediated through projections to the lateral hypothalamus, promotes selective avoidance of food and food-related stimuli. Together, these findings reveal a novel role for the excitatory basal forebrain in regulating appetite suppression through food avoidance mechanisms, highlighting a key function for this structure as a potent integrator of sensory information towards governing consummatory behaviors. eLife Sciences Publications, Ltd 2019-05-10 /pmc/articles/PMC6510534/ /pubmed/31074744 http://dx.doi.org/10.7554/eLife.44548 Text en © 2019, Patel et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Patel, Jay M Swanson, Jessica Ung, Kevin Herman, Alexander Hanson, Elizabeth Ortiz-Guzman, Joshua Selever, Jennifer Tong, Qingchun Arenkiel, Benjamin R Sensory perception drives food avoidance through excitatory basal forebrain circuits |
title | Sensory perception drives food avoidance through excitatory basal forebrain circuits |
title_full | Sensory perception drives food avoidance through excitatory basal forebrain circuits |
title_fullStr | Sensory perception drives food avoidance through excitatory basal forebrain circuits |
title_full_unstemmed | Sensory perception drives food avoidance through excitatory basal forebrain circuits |
title_short | Sensory perception drives food avoidance through excitatory basal forebrain circuits |
title_sort | sensory perception drives food avoidance through excitatory basal forebrain circuits |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510534/ https://www.ncbi.nlm.nih.gov/pubmed/31074744 http://dx.doi.org/10.7554/eLife.44548 |
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