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Sensory perception drives food avoidance through excitatory basal forebrain circuits

Appetite is driven by nutritional state, environmental cues, mood, and reward pathways. Environmental cues strongly influence feeding behavior, as they can dramatically induce or diminish the drive to consume food despite homeostatic state. Here, we have uncovered an excitatory neuronal population i...

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Detalles Bibliográficos
Autores principales: Patel, Jay M, Swanson, Jessica, Ung, Kevin, Herman, Alexander, Hanson, Elizabeth, Ortiz-Guzman, Joshua, Selever, Jennifer, Tong, Qingchun, Arenkiel, Benjamin R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510534/
https://www.ncbi.nlm.nih.gov/pubmed/31074744
http://dx.doi.org/10.7554/eLife.44548
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author Patel, Jay M
Swanson, Jessica
Ung, Kevin
Herman, Alexander
Hanson, Elizabeth
Ortiz-Guzman, Joshua
Selever, Jennifer
Tong, Qingchun
Arenkiel, Benjamin R
author_facet Patel, Jay M
Swanson, Jessica
Ung, Kevin
Herman, Alexander
Hanson, Elizabeth
Ortiz-Guzman, Joshua
Selever, Jennifer
Tong, Qingchun
Arenkiel, Benjamin R
author_sort Patel, Jay M
collection PubMed
description Appetite is driven by nutritional state, environmental cues, mood, and reward pathways. Environmental cues strongly influence feeding behavior, as they can dramatically induce or diminish the drive to consume food despite homeostatic state. Here, we have uncovered an excitatory neuronal population in the basal forebrain that is activated by food-odor related stimuli, and potently drives hypophagia. Notably, we found that the basal forebrain directly integrates environmental sensory cues to govern feeding behavior, and that basal forebrain signaling, mediated through projections to the lateral hypothalamus, promotes selective avoidance of food and food-related stimuli. Together, these findings reveal a novel role for the excitatory basal forebrain in regulating appetite suppression through food avoidance mechanisms, highlighting a key function for this structure as a potent integrator of sensory information towards governing consummatory behaviors.
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spelling pubmed-65105342019-05-13 Sensory perception drives food avoidance through excitatory basal forebrain circuits Patel, Jay M Swanson, Jessica Ung, Kevin Herman, Alexander Hanson, Elizabeth Ortiz-Guzman, Joshua Selever, Jennifer Tong, Qingchun Arenkiel, Benjamin R eLife Neuroscience Appetite is driven by nutritional state, environmental cues, mood, and reward pathways. Environmental cues strongly influence feeding behavior, as they can dramatically induce or diminish the drive to consume food despite homeostatic state. Here, we have uncovered an excitatory neuronal population in the basal forebrain that is activated by food-odor related stimuli, and potently drives hypophagia. Notably, we found that the basal forebrain directly integrates environmental sensory cues to govern feeding behavior, and that basal forebrain signaling, mediated through projections to the lateral hypothalamus, promotes selective avoidance of food and food-related stimuli. Together, these findings reveal a novel role for the excitatory basal forebrain in regulating appetite suppression through food avoidance mechanisms, highlighting a key function for this structure as a potent integrator of sensory information towards governing consummatory behaviors. eLife Sciences Publications, Ltd 2019-05-10 /pmc/articles/PMC6510534/ /pubmed/31074744 http://dx.doi.org/10.7554/eLife.44548 Text en © 2019, Patel et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Patel, Jay M
Swanson, Jessica
Ung, Kevin
Herman, Alexander
Hanson, Elizabeth
Ortiz-Guzman, Joshua
Selever, Jennifer
Tong, Qingchun
Arenkiel, Benjamin R
Sensory perception drives food avoidance through excitatory basal forebrain circuits
title Sensory perception drives food avoidance through excitatory basal forebrain circuits
title_full Sensory perception drives food avoidance through excitatory basal forebrain circuits
title_fullStr Sensory perception drives food avoidance through excitatory basal forebrain circuits
title_full_unstemmed Sensory perception drives food avoidance through excitatory basal forebrain circuits
title_short Sensory perception drives food avoidance through excitatory basal forebrain circuits
title_sort sensory perception drives food avoidance through excitatory basal forebrain circuits
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510534/
https://www.ncbi.nlm.nih.gov/pubmed/31074744
http://dx.doi.org/10.7554/eLife.44548
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