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Facilitation of neuropathic pain by the NPY Y1 receptor-expressing subpopulation of excitatory interneurons in the dorsal horn

Endogenous neuropeptide Y (NPY) exerts long-lasting spinal inhibitory control of neuropathic pain, but its mechanism of action is complicated by the expression of its receptors at multiple sites in the dorsal horn: NPY Y1 receptors (Y1Rs) on post-synaptic neurons and both Y1Rs and Y2Rs at the centra...

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Detalles Bibliográficos
Autores principales: Nelson, Tyler S., Fu, Weisi, Donahue, Renée R., Corder, Gregory F., Hökfelt, Tomas, Wiley, Ronald G., Taylor, Bradley K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510760/
https://www.ncbi.nlm.nih.gov/pubmed/31076578
http://dx.doi.org/10.1038/s41598-019-43493-z