Phosphorylation of 14-3-3ζ links YAP transcriptional activation to hypoxic glycolysis for tumorigenesis

Hypoxic microenvironment deregulates metabolic homeostasis in cancer cells albeit the underlying mechanisms involved in this process remain hitherto enigmatic. 14-3-3ζ/Yes-associated protein (YAP) axis plays a principal role in malignant transformation and tumor development. Here, we report that hyp...

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Detalles Bibliográficos
Autores principales: Jia, Yu, Li, Hui-Yan, Wang, Jue, Wang, Ying, Zhang, Peng, Ma, Ning, Mo, Shi-Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510816/
https://www.ncbi.nlm.nih.gov/pubmed/31076568
http://dx.doi.org/10.1038/s41389-019-0143-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510816/
https://www.ncbi.nlm.nih.gov/pubmed/31076568
http://dx.doi.org/10.1038/s41389-019-0143-1

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