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Hemidesmus indicus induces apoptosis via proteasome inhibition and generation of reactive oxygen species
Proteasome inhibition represents an important anticancer strategy. Here, we studied the mechanisms at the basis of the pro-apoptotic activity of the standardized decoction of Hemidesmus indicus, a plant evoking a complex anticancer activity, and explored its inhibition of proteasome activity in huma...
Autores principales: | Turrini, Eleonora, Catanzaro, Elena, Ferruzzi, Lorenzo, Guerrini, Alessandra, Tacchini, Massimo, Sacchetti, Gianni, Paganetto, Guglielmo, Maffei, Francesca, Pellicioni, Valentina, Poli, Ferruccio, Hrelia, Patrizia, Mandrone, Manuela, Sestili, Piero, Brigotti, Maurizio, Fimognari, Carmela |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510901/ https://www.ncbi.nlm.nih.gov/pubmed/31076590 http://dx.doi.org/10.1038/s41598-019-43609-5 |
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