Dual-drug loaded nanoparticles of Epigallocatechin-3-gallate (EGCG)/Ascorbic acid enhance therapeutic efficacy of EGCG in a APPswe/PS1dE9 Alzheimer's disease mice model

Epigallocatechin-3-gallate (EGCG) is a candidate for treatment of Alzheimer's disease (AD) but its inherent instability limits bioavailability and effectiveness. We found that EGCG displayed increased stability when formulated as dual-drug loaded PEGylated PLGA nanoparticles (EGCG/AA NPs). Oral...

Descripción completa

Detalles Bibliográficos
Autores principales: Cano, Amanda, Ettcheto, Miren, Chang, Jui-Hsien, Barroso, Emma, Espina, Marta, Kühne, Britta A., Barenys, Marta, Auladell, Carmen, Folch, Jaume, Souto, Eliana B., Camins, Antoni, Turowski, Patric, García, Maria Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Publishers 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510952/
https://www.ncbi.nlm.nih.gov/pubmed/30876953
http://dx.doi.org/10.1016/j.jconrel.2019.03.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510952/
https://www.ncbi.nlm.nih.gov/pubmed/30876953
http://dx.doi.org/10.1016/j.jconrel.2019.03.010

Ejemplares similares