Alarmone Ap4A is elevated by aminoglycoside antibiotics and enhances their bactericidal activity

Second messenger molecules play important roles in the responses to various stimuli that can determine a cell's fate under stress conditions. Here, we report that lethal concentrations of aminoglycoside antibiotics result in the production of a dinucleotide alarmone metabolite–diadenosine tetra...

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Detalles Bibliográficos
Autores principales: Ji, Xia, Zou, Jin, Peng, Haibo, Stolle, Anne-Sophie, Xie, Ruiqiang, Zhang, Hongjie, Peng, Bo, Mekalanos, John J., Zheng, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511005/
https://www.ncbi.nlm.nih.gov/pubmed/31004054
http://dx.doi.org/10.1073/pnas.1822026116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511005/
https://www.ncbi.nlm.nih.gov/pubmed/31004054
http://dx.doi.org/10.1073/pnas.1822026116

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