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Alarmone Ap4A is elevated by aminoglycoside antibiotics and enhances their bactericidal activity
Second messenger molecules play important roles in the responses to various stimuli that can determine a cell's fate under stress conditions. Here, we report that lethal concentrations of aminoglycoside antibiotics result in the production of a dinucleotide alarmone metabolite–diadenosine tetra...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511005/ https://www.ncbi.nlm.nih.gov/pubmed/31004054 http://dx.doi.org/10.1073/pnas.1822026116 |