The crystal structure of dGTPase reveals the molecular basis of dGTP selectivity

Deoxynucleotide triphosphohydrolases (dNTPases) play a critical role in cellular survival and DNA replication through the proper maintenance of cellular dNTP pools. While the vast majority of these enzymes display broad activity toward canonical dNTPs, such as the dNTPase SAMHD1 that blocks reverse...

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Detalles Bibliográficos
Autores principales: Barnes, Christopher O., Wu, Ying, Song, Jinhu, Lin, Guowu, Baxter, Elizabeth L., Brewster, Aaron S., Nagarajan, V., Holmes, Andrew, Soltis, S. Michael, Sauter, Nicholas K., Ahn, Jinwoo, Cohen, Aina E., Calero, Guillermo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511015/
https://www.ncbi.nlm.nih.gov/pubmed/31019074
http://dx.doi.org/10.1073/pnas.1814999116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511015/
https://www.ncbi.nlm.nih.gov/pubmed/31019074
http://dx.doi.org/10.1073/pnas.1814999116

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