Cargando…

The crystal structure of dGTPase reveals the molecular basis of dGTP selectivity

Deoxynucleotide triphosphohydrolases (dNTPases) play a critical role in cellular survival and DNA replication through the proper maintenance of cellular dNTP pools. While the vast majority of these enzymes display broad activity toward canonical dNTPs, such as the dNTPase SAMHD1 that blocks reverse...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barnes, Christopher O., Wu, Ying, Song, Jinhu, Lin, Guowu, Baxter, Elizabeth L., Brewster, Aaron S., Nagarajan, V., Holmes, Andrew, Soltis, S. Michael, Sauter, Nicholas K., Ahn, Jinwoo, Cohen, Aina E., Calero, Guillermo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511015/ https://www.ncbi.nlm.nih.gov/pubmed/31019074 http://dx.doi.org/10.1073/pnas.1814999116

Ejemplares similares

Mechanism of Allosteric Activation of SAMHD1 by dGTP
por: Ji, Xiaoyun, et al.
Publicado: (2013)

RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases
por: Shi, Geng-Xian, et al.
Publicado: (2018)

Distinct sets of tethering complexes, SNARE complexes, and Rab GTPases mediate membrane fusion at the vacuole in Arabidopsis
por: Takemoto, Kodai, et al.
Publicado: (2018)

LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis
por: Eguchi, Tomoya, et al.
Publicado: (2018)

Activity-dependent bulk endocytosis proteome reveals a key presynaptic role for the monomeric GTPase Rab11
por: Kokotos, A. C., et al.
Publicado: (2018)

Rates of niche and phenotype evolution lag behind diversification in a temperate radiation
por: Folk, Ryan A., et al.
Publicado: (2019)

An endogenous dAMP ligand in Bacillus subtilis class Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP
por: Parker, Mackenzie J., et al.
Publicado: (2018)

dGTP Starvation in Escherichia coli Provides New Insights into the Thymineless-Death Phenomenon
por: Itsko, Mark, et al.
Publicado: (2014)

Asymmetries between achromatic and chromatic extraction of 3D motion signals
por: Kaestner, Milena, et al.
Publicado: (2019)

Positive selection in dNTPase SAMHD1 throughout mammalian evolution
por: Monit, Christopher, et al.
Publicado: (2019)

Analysis of high-resolution 3D intrachromosomal interactions aided by Bayesian network modeling
por: Zhang, Xizhe, et al.
Publicado: (2017)

Control of growth and gut maturation by HoxD genes and the associated lncRNA Haglr
por: Zakany, Jozsef, et al.
Publicado: (2017)

Leveraging protein dynamics to identify cancer mutational hotspots using 3D structures
por: Kumar, Sushant, et al.
Publicado: (2019)

Dorsal striatal dopamine D1 receptor availability predicts an instrumental bias in action learning
por: de Boer, Lieke, et al.
Publicado: (2019)

Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells
por: Tavera-Mendoza, Luz E., et al.
Publicado: (2017)

Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception
por: Long, Jonathan Z., et al.
Publicado: (2018)

Suppressor mutation analysis combined with 3D modeling explains cohesin’s capacity to hold and release DNA
por: Xu, Xingya, et al.
Publicado: (2018)

Synthetic far-red light-mediated CRISPR-dCas9 device for inducing functional neuronal differentiation
por: Shao, Jiawei, et al.
Publicado: (2018)

Coupling between dynamic 3D tissue architecture and BMP morphogen signaling during Drosophila wing morphogenesis
por: Gui, Jinghua, et al.
Publicado: (2019)

Structural characterization of the D290V mutation site in hnRNPA2 low-complexity–domain polymers
por: Murray, Dylan T., et al.
Publicado: (2018)

Multifunctionalized hydrogels foster hNSC maturation in 3D cultures and neural regeneration in spinal cord injuries
por: Marchini, Amanda, et al.
Publicado: (2019)

Selective fertilization with phosphite allows unhindered growth of cotton plants expressing the ptxD gene while suppressing weeds
por: Pandeya, Devendra, et al.
Publicado: (2018)

Parkinson’s disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration
por: Chen, Xi, et al.
Publicado: (2019)

The active site of TthPolX is adapted to prevent 8-oxo-dGTP misincorporation
por: Garrido, Patricia, et al.
Publicado: (2014)

SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP
por: Davenne, Tamara, et al.
Publicado: (2020)

Mechanism by which T7 bacteriophage protein Gp1.2 inhibits Escherichia coli dGTPase
por: Klemm, Bradley P., et al.
Publicado: (2022)

Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk
por: Hlusko, Leslea J., et al.
Publicado: (2018)

Dopamine D2 receptor-mediated circuit from the central amygdala to the bed nucleus of the stria terminalis regulates impulsive behavior
por: Kim, Bokyeong, et al.
Publicado: (2018)

The evolution and genomic basis of beetle diversity
por: McKenna, Duane D., et al.
Publicado: (2019)

The olfactory basis of orchid pollination by mosquitoes
por: Lahondère, Chloé, et al.
Publicado: (2020)

Laterally confined growth of cells induces nuclear reprogramming in the absence of exogenous biochemical factors
por: Roy, Bibhas, et al.
Publicado: (2018)

Structural basis of human kinesin-8 function and inhibition
por: Locke, Julia, et al.
Publicado: (2017)

Metabolic and genetic basis for auxotrophies in Gram-negative species
por: Seif, Yara, et al.
Publicado: (2020)

Quantifying the transmission dynamics of MRSA in the community and healthcare settings in a low-prevalence country
por: Di Ruscio, Francesco, et al.
Publicado: (2019)

Structural basis for antiarrhythmic drug interactions with the human cardiac sodium channel
por: Nguyen, Phuong T., et al.
Publicado: (2019)

Structural basis for adenylation and thioester bond formation in the ubiquitin E1
por: Hann, Zachary S., et al.
Publicado: (2019)

Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein
por: Oyen, David, et al.
Publicado: (2017)

Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA
por: Ferron, François, et al.
Publicado: (2018)

Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus
por: Jayawardena, Nadishka, et al.
Publicado: (2018)

MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP
por: Jemth, Ann-Sofie, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_lps1n98ln0smf36nt17h0b9fsf