Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance

The RAS family of proto-oncogenes are among the most commonly mutated genes in human cancers and predict poor clinical outcome. Several mechanisms underlying oncogenic RAS transformation are well documented, including constitutive signaling through the RAF-MEK-ERK proproliferative pathway as well as...

Descripción completa

Detalles Bibliográficos
Autores principales: Lim, Jonathan K. M., Delaidelli, Alberto, Minaker, Sean W., Zhang, Hai-Feng, Colovic, Milena, Yang, Hua, Negri, Gian Luca, von Karstedt, Silvia, Lockwood, William W., Schaffer, Paul, Leprivier, Gabriel, Sorensen, Poul H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511045/
https://www.ncbi.nlm.nih.gov/pubmed/31000598
http://dx.doi.org/10.1073/pnas.1821323116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511045/
https://www.ncbi.nlm.nih.gov/pubmed/31000598
http://dx.doi.org/10.1073/pnas.1821323116

Ejemplares similares