Cargando…

Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance

The RAS family of proto-oncogenes are among the most commonly mutated genes in human cancers and predict poor clinical outcome. Several mechanisms underlying oncogenic RAS transformation are well documented, including constitutive signaling through the RAF-MEK-ERK proproliferative pathway as well as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lim, Jonathan K. M., Delaidelli, Alberto, Minaker, Sean W., Zhang, Hai-Feng, Colovic, Milena, Yang, Hua, Negri, Gian Luca, von Karstedt, Silvia, Lockwood, William W., Schaffer, Paul, Leprivier, Gabriel, Sorensen, Poul H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511045/ https://www.ncbi.nlm.nih.gov/pubmed/31000598 http://dx.doi.org/10.1073/pnas.1821323116

Ejemplares similares

Cystine–glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity
por: Arensman, Michael D., et al.
Publicado: (2019)

The Role of Cystine/Glutamate Antiporter SLC7A11/xCT in the Pathophysiology of Cancer
por: Jyotsana, Nidhi, et al.
Publicado: (2022)

The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility
por: Shin, Chun-Shik, et al.
Publicado: (2017)

Implication of the glutamate–cystine antiporter xCT in schizophrenia cases linked to impaired GSH synthesis
por: Fournier, M., et al.
Publicado: (2017)

Cystine/Glutamate Antiporter (xCT) Is Required for Chief Cell Plasticity After Gastric Injury
por: Meyer, Anne R., et al.
Publicado: (2019)

Immunotherapy against the Cystine/Glutamate Antiporter xCT Improves the Efficacy of APR-246 in Preclinical Breast Cancer Models
por: Barutello, Giuseppina, et al.
Publicado: (2022)

Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction
por: Hillig, Roman C., et al.
Publicado: (2019)

Rotavirus-induced lncRNA SLC7A11-AS1 promotes ferroptosis by targeting cystine/glutamate antiporter xCT (SLC7A11) to facilitate virus infection
por: Banerjee, Shreya, et al.
Publicado: (2023)

The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor
por: LeVine, Michael V., et al.
Publicado: (2019)

Cystine/glutamate antiporter xCT deficiency reduces metastasis without impairing immune system function in breast cancer mouse models
por: Ruiu, Roberto, et al.
Publicado: (2023)

Mutually inhibitory Ras-PI(3,4)P(2) feedback loops mediate cell migration
por: Li, Xiaoguang, et al.
Publicado: (2018)

Increased expression of cystine/glutamate antiporter in multiple sclerosis
por: Pampliega, Olatz, et al.
Publicado: (2011)

Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer
por: Morotti, Matteo, et al.
Publicado: (2019)

Genetic deletion of vesicular glutamate transporter in dopamine neurons increases vulnerability to MPTP-induced neurotoxicity in mice
por: Shen, Hui, et al.
Publicado: (2018)

M-Ras/Shoc2 signaling modulates E-cadherin turnover and cell–cell adhesion during collective cell migration
por: Kota, Pradeep, et al.
Publicado: (2019)

Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity
por: Kleiner, Sandra, et al.
Publicado: (2018)

Overexpression of Cystine/Glutamate Antiporter xCT Correlates with Nutrient Flexibility and ZEB1 Expression in Highly Clonogenic Glioblastoma Stem-like Cells (GSCs)
por: Koch, Katharina, et al.
Publicado: (2021)

Change of cystine/glutamate antiporter expression in ethanol-dependent rats
por: Peana, Alessandra T., et al.
Publicado: (2014)

Identification, Expression, and Roles of the Cystine/Glutamate Antiporter in Ocular Tissues
por: Martis, Renita M., et al.
Publicado: (2020)

Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease
por: Vallerga, Costanza L., et al.
Publicado: (2020)

Remote optimization of an ultracold atoms experiment by experts and citizen scientists
por: Heck, Robert, et al.
Publicado: (2018)

The System xc- Cystine/Glutamate Antiporter: An Exciting Target for Antiepileptogenic Therapy?
por: Gallagher, Martin
Publicado: (2020)

Recurrence is required to capture the representational dynamics of the human visual system
por: Kietzmann, Tim C., et al.
Publicado: (2019)

Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase
por: Imberdis, Thibaut, et al.
Publicado: (2019)

Corticostriatal dysfunction and social interaction deficits in mice lacking the cystine/glutamate antiporter
por: Bentea, Eduard, et al.
Publicado: (2020)

Cystine/Glutamate Antiporter in Schizophrenia: From Molecular Mechanism to Novel Biomarker and Treatment
por: Hung, Chung-Chieh, et al.
Publicado: (2021)

Molecular basis for redox control by the human cystine/glutamate antiporter system xc(−)
por: Parker, Joanne L., et al.
Publicado: (2021)

Early Onset of Age-Related Cataracts in Cystine/Glutamate Antiporter Knockout Mice
por: Martis, Renita Maria, et al.
Publicado: (2021)

A hypothesis linking the energy demand of the brain to obesity risk
por: Kuzawa, Christopher W., et al.
Publicado: (2019)

CFH and ARMS2 genetic risk determines progression to neovascular age-related macular degeneration after antioxidant and zinc supplementation
por: Vavvas, Demetrios G., et al.
Publicado: (2018)

Uniquely human CHRFAM7A gene increases the hematopoietic stem cell reservoir in mice and amplifies their inflammatory response
por: Costantini, Todd W., et al.
Publicado: (2019)

Evolution of vertical and oblique transmission under fluctuating selection
por: Ram, Yoav, et al.
Publicado: (2018)

High-Throughput Assay Development for Cystine-Glutamate Antiporter (x(c) (-)) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells
por: Thomas, Ajit G., et al.
Publicado: (2015)

Organizing principles for the cerebral cortex network of commissural and association connections
por: Swanson, Larry W., et al.
Publicado: (2017)

Lawful tracking of visual motion in humans, macaques, and marmosets in a naturalistic, continuous, and untrained behavioral context
por: Knöll, Jonas, et al.
Publicado: (2018)

Themis-associated phosphatase activity controls signaling in T cell development
por: Mehta, Monika, et al.
Publicado: (2018)

Projecting one’s own spatial bias onto others during a theory-of-mind task
por: Bio, Branden J., et al.
Publicado: (2018)

Evolution of resilience in protein interactomes across the tree of life
por: Zitnik, Marinka, et al.
Publicado: (2019)

Diagnosing Alzheimer’s Disease Specifically and Sensitively With pLG72 and Cystine/Glutamate Antiporter SLC7A11 AS Blood Biomarkers
por: Lane, Hsien-Yuan, et al.
Publicado: (2022)

Pairwise comparisons across species are problematic when analyzing functional genomic data
por: Dunn, Casey W., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_fcuofk0ufvav2jjcrcth0501a4