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HIV-1 Vpr counteracts HLTF-mediated restriction of HIV-1 infection in T cells

Lentiviruses, including HIV-1, possess the ability to enter the nucleus through nuclear pore complexes and can infect interphase cells, including those actively replicating chromosomal DNA. Viral accessory proteins hijack host cell E3 enzymes to antagonize intrinsic defenses, and thereby provide a m...

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Detalles Bibliográficos
Autores principales: Yan, Junpeng, Shun, Ming-Chieh, Zhang, Yi, Hao, Caili, Skowronski, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511057/
https://www.ncbi.nlm.nih.gov/pubmed/31019079
http://dx.doi.org/10.1073/pnas.1818401116