Cargando…

Relative effects of LDL-C on ischemic stroke and coronary disease: A Mendelian randomization study

OBJECTIVE: To examine the causal relevance of lifelong differences in low-density lipoprotein cholesterol (LDL-C) for ischemic stroke (IS) relative to that for coronary heart disease (CHD) using a Mendelian randomization approach. METHODS: We undertook a 2-sample Mendelian randomization, based on su...

Descripción completa

Detalles Bibliográficos
Autores principales:	Valdes-Marquez, Elsa, Parish, Sarah, Clarke, Robert, Stari, Traiani, Worrall, Bradford B., Hopewell, Jemma C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511103/ https://www.ncbi.nlm.nih.gov/pubmed/30787162 http://dx.doi.org/10.1212/WNL.0000000000007091

Ejemplares similares

Differential effects of PCSK9 variants on risk of coronary disease and ischaemic stroke
por: Hopewell, Jemma C, et al.
Publicado: (2018)

Mendelian randomization with fine‐mapped genetic data: Choosing from large numbers of correlated instrumental variables
por: Burgess, Stephen, et al.
Publicado: (2017)

Genetic associations of adult height with risk of cardioembolic and other subtypes of ischemic stroke: A mendelian randomization study in multiple ancestries
por: Linden, Andrew B., et al.
Publicado: (2022)

Plasma cytokines and risk of coronary heart disease in the PROCARDIS study
por: Clarke, Robert, et al.
Publicado: (2018)

A key risk indicator approach to central statistical monitoring in multicentre clinical trials: method development in the context of an ongoing large-scale randomized trial
por: Elsa, Valdés-Márquez, et al.
Publicado: (2011)

Assessment of the causal relevance of ECG parameters for risk of atrial fibrillation: A mendelian randomisation study
por: Gajendragadkar, Parag Ravindra, et al.
Publicado: (2021)

Central statistical monitoring in multicentre clinical trials: developing statistical approaches for analysing key risk indicators
por: Valdes-Marquez, Elsa, et al.
Publicado: (2013)

Improving efficiency of on-site monitoring in multicentre clinical trials by targeting visits
por: Knott, Carol, et al.
Publicado: (2015)

Migraine and Ischemic Stroke: A Mendelian Randomization Study
por: Shu, Mei-Jun, et al.
Publicado: (2021)

Causal associations of insulin resistance with coronary artery disease and ischemic stroke: a Mendelian randomization analysis
por: Chen, Weiqi, et al.
Publicado: (2020)

Investigating the association of atopic dermatitis with ischemic stroke and coronary heart disease: A mendelian randomization study
por: Huang, Jian, et al.
Publicado: (2022)

Educational Attainment and Ischemic Stroke: A Mendelian Randomization Study
por: Gao, Luyan, et al.
Publicado: (2022)

Investigating the causal effect of Dickkopf-1 on coronary artery disease and ischemic stroke: a Mendelian randomization study
por: Zheng, Peng-Fei, et al.
Publicado: (2023)

Inflammatory Cytokines and Risk of Ischemic Stroke: A Mendelian Randomization Study
por: Li, Yalan, et al.
Publicado: (2022)

A Bidirectional Mendelian Randomization Study of Selenium Levels and Ischemic Stroke
por: Fang, Hui, et al.
Publicado: (2022)

Independent effects of adiposity measures on risk of atrial fibrillation in men and women: a study of 0.5 million individuals
por: Camm, C Fielder, et al.
Publicado: (2021)

Impact of Apolipoprotein(a) Isoform Size on Lipoprotein(a) Lowering in the HPS2-THRIVE Study
por: Parish, Sarah, et al.
Publicado: (2018)

LDL-C plays a causal role on T2DM: a Mendelian randomization analysis
por: Pan, Wenbin, et al.
Publicado: (2020)

Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study
por: Larsson, Susanna C., et al.
Publicado: (2019)

Heart Failure and Ischemic Stroke: A Bidirectional and Multivariable Mendelian Randomization Study
por: Zhang, Luyang, et al.
Publicado: (2021)

Genetic insights into the risk of snoring on stroke and ischemic stroke: A single-variable and multivariable Mendelian randomization
por: He, Qiang, et al.
Publicado: (2022)

A Mendelian randomization analysis of the relationship between cardioembolic risk factors and ischemic stroke
por: Tian, Danyang, et al.
Publicado: (2021)

Ischemic Stroke and Cerebral Microbleeds: A Two-Sample Bidirectional Mendelian Randomization Study
por: Liu, Renjie, et al.
Publicado: (2023)

Women's reproductive traits and ischemic stroke: a two‐sample Mendelian randomization study
por: Wang, Zhenqian, et al.
Publicado: (2022)

Mendelian randomization study on the causal effects of tumor necrosis factor inhibition on coronary artery disease and ischemic stroke among the general population
por: Kang, Xiaoying, et al.
Publicado: (2022)

Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study
por: Hopewell, Jemma C., et al.
Publicado: (2013)

Lifelong Reduction of LDL-Cholesterol Related to a Common Variant in the LDL-Receptor Gene Decreases the Risk of Coronary Artery Disease—A Mendelian Randomisation Study
por: Linsel-Nitschke, Patrick, et al.
Publicado: (2008)

Mendelian randomization study reveals a causal relationship between adiponectin and LDL cholesterol in Africans
por: Meeks, Karlijn A. C., et al.
Publicado: (2022)

Transient ischemic attack and coronary artery disease: a two-sample Mendelian randomization analysis
por: Qi, Xiaoyi, et al.
Publicado: (2023)

Role of Blood Lipids in the Development of Ischemic Stroke and its Subtypes: A Mendelian Randomization Study
por: Hindy, George, et al.
Publicado: (2018)

No Causal Effect of Telomere Length on Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study
por: Cao, Weijie, et al.
Publicado: (2019)

Role of cigarette smoking in the development of ischemic stroke and its subtypes: a Mendelian randomization study
por: Qian, Yu, et al.
Publicado: (2019)

Causal Effects of Sleep Traits on Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study
por: Cai, Huan, et al.
Publicado: (2020)

Intercellular adhesion molecule 4 and ischemic stroke: a two-sample Mendelian randomization study
por: Sun, Lulu, et al.
Publicado: (2023)

Electronegative LDL Is Associated with Plaque Vulnerability in Patients with Ischemic Stroke and Carotid Atherosclerosis
por: Puig, Núria, et al.
Publicado: (2023)

Physical activity, sedentary behavior and risk of coronary artery disease, myocardial infarction and ischemic stroke: a two-sample Mendelian randomization study
por: Bahls, Martin, et al.
Publicado: (2021)

The Ischemic Stroke Genetics Study (ISGS) Protocol
por: Meschia, James F, et al.
Publicado: (2003)

Correction: Lifelong Reduction of LDL-Cholesterol Related to a Common Variant in the LDL-Receptor Gene Decreases the Risk of Coronary Artery Disease—A Mendelian Randomisation Study
por: Linsel-Nitschke, Patrick, et al.
Publicado: (2008)

Pentraxin 3, TNF-α, and LDL-C Are Associated With Carotid Artery Stenosis in Patients With Ischemic Stroke
por: Yi, Li, et al.
Publicado: (2020)

Roles for circulating polyunsaturated fatty acids in ischemic stroke and modifiable factors: a Mendelian randomization study
por: Yuan, Tonghui, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ecvnmu609j5deic1gn926d1f9g